Software Patches

Operating System Updates

Illumina encourages customers to apply Illumina-tested operating system security patches on a regular basis. Illumina tests critical operating system security patches to ensure compatibility with Illumina systems running the most recent version of instrument control software.

Installing Windows and Linux Operating System updates

To install and configure your Windows or Linux Operating System updates, refer to the table below for downloadable instructions and links to instrument-specific patches.

Most updates are cumulative. This means that older patches are rolled into the most recent patch listed.

Windows automatic operating system security updates are disabled by default on your Illumina system. If you enable automatic system updates, it is possible that you may install untested updates that could impact system integrity.
OS Security Patch Download and Installation Instructions

Locate your instrument in the table and download both PDF files. Make sure to read the installation instructions prior to installing the patches.

Instrument Scheduled Release Instructions and Patches
iScan Late Q2 2024 Coming soon.
iSeq 100 Q2 2024
  • Read first — Installation instructions 
  • iSeq security patches
MiniSeq Q2 2024
  • Read first — Installation instructions
  • MiniSeq security patches
MiSeq Late Q2 2024

Coming soon.
MiSeqDx Q2 2024

For RUO system and RUO mode of MiSeqDx instrument

  • Read first — Installation instructions 
  • MiSeqDx patches (Dx mode only)
NextSeq 1000/2000 Q2 2024
  • Follow guidance in NextSeq 1000/2000 system guide for CentOS updates [***Our policy is to not provide direct links to docs or topics in docs as they can change and we run the risk of the link breaking.***]
  • NextSeq 1000/2000 patches
NextSeq 500/550 Late Q2 2024 Coming soon.
NextSeq 550Dx Q2 2024

For RUO system and RUO mode of NextSeqDx instrument

  • Read first — Installation instructions 
  • NextSeq 550Dx patches (Dx mode only)
NovaSeq 6000 Late Q2 2024 Coming soon.
NovaSeq Dx Q2 2024
  • Read first — Installation instructions 
  • NovaSeq Dx patches
NovaSeq X Plus Late Q2 2024 Coming soon.

 

If you are unable to install operating system security patches per your internal security policy, the following are recommended alternatives:

  • Place the system on an isolated network.
  • Utilize an air-gapped network attached storage (NAS) appliance that allows data to sync to the network.
  • Apply the appropriate permission-based controls to user accounts.
  • Make sure that the instrument control computer is only used for the operation of the Illumina sequencing system, and is not used as a general purpose computer. For more information, refer to User Behavior.